strongest lidocaine cream otc

The Strongest Lidocaine Creams That Are Available OTC

This article was reviewed by Dr. Emilija Ashtalkoska on August 11th, 2018. Products listed therein are not intended to diagnose, treat, cure, or prevent any disease or health condition.


Lidocaine is one of the most popular numbing medications available on the market today.

Many people use it to reduce or eliminate pain when getting a tattoo, experiencing sunburn, hemorrhoids, poison ivy, burns, or just general pain.

Regardless of what you need lidocaine for, it is important to understand that not all lidocaine creams are the same. In fact, they can substantially vary in terms of lidocaine concentration.

Continue reading to view our top recommendations for the strongest lidocaine creams otc today. Please note that this website does not provide medical advice.

Talk to your doctor before using lidocaine cream, or any other local anesthetic.

Don’t have a lot of time? Click here to go directly to the product page for our top recommendation, Ebanel Numb 520 5% Lidocaine on

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Ebanel 5% Lidocaine Topical Numbing Cream for Painkilling, 4.38oz Max Strength Pain Relief Cream Ointment...
Ebanel Numb 520 5% Lidocaine
Maximum strength, FDA registered, works in just 3-5 minutes

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Uber Numb 5% Lidocaine Topical Anesthetic Cream Advanced Formula Rapid Absorption Non-Oily (4 Ounce (NCR))
UberNumb Pain Relief Cream
5% lidocaine solution, also includes Vitamin E to moisture skin and prevent inflammation

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Zensa numbing Cream — Maximum Strength Topical Anesthetic
Zensa Numbing Cream
FDA approved solution that is favored by tattoo artists, spa technicians, and hair removal clinics

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Clinical Resolution Non-oily Numb Master Topical Anesthetic Cream (12 oz (3 jars x 4oz))
Numb Master 5% Lidocaine
Made in USA, the best solution for anyone who needs to purchase 5% lidocaine in bulk

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1. Ebanel Numb 520 5% Lidocaine

Ebanel 5% Lidocaine Topical Numbing Cream for Painkilling, 4.38oz Max Strength Pain Relief Cream Ointment...

Ebanel Numb 520 5% Lidocaine is one of the most popular and powerful topical numbing creams available today.

The topical analgesic starts working in just 3 to 5 minutes and can help numb discomfort, pain, and burning sensations.

By utilizing the power of Liposomal technology, the cream reaches its maximum numbing effect in twenty minutes and the effect lasts for an hour. If needed, you can reapply the solution up to six times a day.

Additionally, the anesthetic cream is manufactured in an FDA registered facility to ensure quality.

When you factor in all of these different points, it is clear the Ebanel has created one of the best and strongest lidocaine creams that are available for purchase OTC.

We highly recommend utilizing this over-the-counter lidocaine solution for your pain needs.

Click here to view Ebanel Numb 520 Cream on

2. UberNumb Pain Relief Cream

Uber Numb 5% Lidocaine Topical Anesthetic Cream Advanced Formula Rapid Absorption Non-Oily (4 Ounce (NCR))

UberNumb Pain Relief Cream is an incredible lidocaine cream that utilizes the maximum dosage of 5% allowed by the FDA in non-prescription creams.

It starts working immediately and reaches peak numbness in 20-25 minutes.

UberNumb utilizes a powerful non-oily formula, making it perfect for people who are prone to breakouts and other skin issues.

It is enriched with Vitamin E to not only numb the applied site, but also moisturize your skin and prevent inflammation.

This moisturizing effect is absolutely incredible, as many other anesthetic creams can actually dry out the skin. But not UberNumb!

Also, many of our readers may be happy to know that UberNumb is 100% American Made and comes with a fantastic 100% money back guarantee if you are unsatisfied at all with your purchase.

If you need a high-quality over-the-counter lidocaine cream that works quickly, UberNumb is a fantastic choice.

Click here to view UberNumb Pain Relief Cream on

3. Zensa Maximum Strength Topical Anesthetic Numbing Cream

Zensa numbing Cream — Maximum Strength Topical Anesthetic

Zensa Maximum Strength Topical Anesthetic Numbing Cream is an FDA approved solution that features 5% lidocaine. It provides a numbing sensation within minutes and is backed by extensive research and development.

Simply apply two layers five minutes apart for maximum effect. In certain stances, Zensa can last up to three hours, making it one of the longest lasting numbing creams on the market.

This is a tremendous duration and is significantly longer than most other lidocaine creams available.

Zensa is the topical anesthetic that is favored by the tattooing community, hair removal clinics, and various spas all over the world. It doesn’t constrict any blood, making it especially useful in the world of body art and inking.

Fortunately, this strong formula can be purchased over the counter by clicking the link below.

Zensa Maximum Strength Topical Anesthetic Numbing Cream is another phenomenal anesthetic, and is our top recommendation if you are looking for a numbing cream for tattooing or piercings.

Click here to view Zensa Maximum Strength Numbing Cream on

4. Numb Master 5% Lidocaine

Clinical Resolution Non-oily Numb Master Topical Anesthetic Cream (12 oz (3 jars x 4oz))

Numb Master 5% Topical Anesthetic Lidocaine Cream is a fast acting numbing gel that lasts about an hour depending on your body type and reaction.

It utilizes a strong form of liposomal lidocaine that leads to deeper penetration, and thus a strong numbing effect.

It is made in the USA, and can be applied to up six times a day. Most people will experience maximum numbing effects within 20-25 minutes.

The Numb Master cream is a particularly great deal if you need to utilize a lot of lidocaine cream because of the ability to purchase a large amount of the cream.

If you are a spa technician or a tattoo artist, or just experience a ton of pain, this is a great solution for you. Click here to view the Numb Master value pack.

Click here to view Numb Master 5% Topical Anesthetic Lidocaine Cream on

How To Apply Over The Counter Lidocaine Cream

lidocaine cream

In reality, applying lidocaine cream will depend on what you need the numbing effect for.

For example, utilizing lidocaine cream for back pain will be different than using it before a tattoo session. However, these are some general directions you can follow to utilize the numbing effects of lidocaine.

Please consult a medical professional before introducing any new treatment to your body. This website does not provide any medical advice.

1. Prepare The Site

If feasible, clean the application site with warm water and mild soap, and then dry the skin by lightly patting it with a towel or cloth.

Cleaning the skin beforehand will help maximize the numbing effect of the lidocaine cream and prevent any additional messiness.

It is also to remove any dirt or other residual contaminants on the skin which could negate the effect of the lidocaine or prevent the cream from working in the first place.

2. Test Your Reaction

We always recommend consulting with your doctor before introducing any new medication.

Once you have consulted with your doctor, do an allergy test by applying a small amount of lidocaine to the site using a q-tip or cotton ball.

Additionally, it is important to see how effective lidocaine is for you.

It is reported that lidocaine may not work effectively for everyone since every one has slightly different body chemistry, so it is important to test your results before undergoing any procedure.

Wait a few minutes to see if you have any sort of allergic reaction. If you do, seek medical attention immediately.

If you do not have an adverse reaction and experience a numbing effect, you can now be reasonably certain that lidocaine cream works well with your body. Talk to your doctor to confirm.

3. Apply The Lidocaine Cream

Utilizing gloves, a cloth, or q-tips, apply lidocaine directly to the needed site. Depending on which cream you have chosen, you should start feeling numbness within five minutes or so.

This should reach full effect within 20-30 minutes and keep numbing for an hour or more, depending on the cream.

Please keep in mind that these times are just estimates and that every body can react slightly differently to anesthetics.

After the numbing effects of the lidocaine start declining you may want to reapply a second coat if needed.

Make sure you follow the specific directions of the lidocaine you chose though, as the ingredients and thus directions may differ.

Once your treatment is over, you may remove any excess cream using a washcloth with warm water and light soap.

Make sure the cream is completely removed from your skin, and then wash your hands if you administered the application of the cream.

Does Lidocaine Cream Work For Back Pain, Shingles, Tattoos, Etc?

strongest lidocaine cream otc

Lidocaine cream can be applied to most external parts of the body without issue.

It is never approved for internal usage, so we do not recommend applying to your eyes, nose, genitalia, tongue, or any other sensitive part of the body.

In any instance, we recommend doing an allergy test by placing a small portion of lidocaine on your body to see if you have a reaction.

Although rare, allergic reactions are possible. Always consult a medical professional before introducing a new treatment, even if it is over the counter. This website does not provide medical advice.

How Does Lidocaine Cream Work?

Lidocaine works by blocking the pain signals that originate from the nerves in your body. This works because lidocaine hydrochloride is known as a local anesthetic, meaning it temporarily numbs painful areas.

On a technical level, it actually does this by blocking sodium from the nerve ending, which essentially prevents the brain from receiving the pain signal from the nerve fibers.

How Long Will 5% Lidocaine Work For?

5% lidocaine, the strongest amount allowed over-the-counter in the United States, will keep your skin numb anywhere from an hour to ninety minutes.

This duration can depend on a number of biological factors, but that for most people, the numbing duration will last somewhere in this range.

This is is just an estimate, so keep in mind that the numbing effect may last longer or shorter when applied to your skin.

Are There Any Possible Side-Effects?

Like any topical treatment, there is a small possibility of experiencing side-effects. The most common side effects include itching, irritation, and reddening of the skin at the contact site.

However, it is possible to have a more severe adverse reaction, which may include swelling, heavy breathing, coughing, and other common adverse reactions.

We always recommend consulting your doctor before introducing your body to a new treatment, and after you have gotten permission from a medical professional, apply a small amount of lidocaine as an allergy test before using a major amount.

Also, it is important to keep in mind that lidocaine, like many chemicals, can interfere with any medications you are prescribed.

This is another reason why it is so important to talk to your doctor before using numbing cream or any other anesthetic.

Can I Use Lidocaine Cream If I’m Pregnant?

If you are pregnant or breastfeeding we recommend consulting your doctor before using lidocaine cream or any other medication.

We also recommend consulting your doctor before applying lidocaine or any other medication to children of any age. This website does not provide medical advice.

What Is The Strongest Lidocaine Dosage Allowed Over The Counter?

lidocaine cream

In the United States, the FDA allows a dosage of up to 5% lidocaine in over the counter treatments. Higher dosages may be prescribed by a doctor in certain instances.

It may be possible to find 10% or even 20% creams from unscrupulous internet vendors.

It is extremely dangerous to use these creams without supervised medical attention, so please do not mess around with any of these potent creams.

This website does not provide medical advice, please consult a medical professional before introducing your body to any drug.

Fortunately, all of the lidocaine creams listed above feature the maximum dosage allowed – 5%.

This makes all of these creams a fantastic over the counter choice. Pick not only the strongest lidocaine cream otc, but also one that is a safe dosage.

Where Is The Best Place To Purchase Strong Lidocaine Cream OTC?

Many of our readers ask us if they should purchase lidocaine cream at Walmart, Costco, CVS, Walgreens, or even on eBay. We recommend purchasing lidocaine cream on

Click here to view our top recommended lidocaine cream, Ebanel Numb 520 5% on


Lidocaine cream is one of the most popular topical analgesic solutions on the market today. People all over the world use it for back pain, tattooing, waxing, etc.

Doctors even use it when dealing with surgical treatments of nail fungus.

Regardless of your needs, we hope you enjoyed reading this article about the strongest lidocaine creams that are available over the counter, and we hope you learned a thing or two about numbing creams!

Feel free to leave a comment below to tell us about your experience with lidocaine creams. Thank you for reading this article on the strongest lidocaine cream otc.

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